Journal: Advances in Pharmacological and Pharmaceutical Sciences
Article Title: Cilostazol Combats Lipopolysaccharide-Induced Hippocampal Injury in Rats: Role of AKT/GSK3 β /CREB Curbing Neuroinflammation
doi: 10.1155/2024/3465757
Figure Lengend Snippet: Effect of cilostazol on rat hippocampal contents of caspase-3 (a), B-cell lymphoma 2 (BCL2) (b), nuclear factor kappa B (NF- κ B) (c), and brain-derived neurotrophic factor (BDNF) (d) in LPS-induced neurobehavioral deficit ( n = 10). Bars are presented as mean ± SEM. A P < 0.05 vs. control; B P < 0.05 vs. LPS.
Article Snippet: Hippocampal biochemical contents were determined with the aid of rat amyloid beta peptide 1–42 (A β 1-42), rat phospho-tau protein (p-tau) ELISA, rat nuclear factor kappa B (NF- κ B), rat brain-derived neurotrophic factor (BDNF), rat cyclic AMP response element-binding protein (CREB), rat phospho cyclic AMP response element-binding protein (p-CREB), rat caspase-3, rat B-cell leukemia/lymphoma 2 (BCL2), rat phospho-glycogen synthase kinase-3 beta, and p-Akt (Phospho-Ser473) kits, obtained from MyBioSource, San Diego, USA (cat#: MBS726579, MBS764464, MBS453975, MBS355345, MBS266581, MBS7255484, MBS018987, MBS452319, MBS730623, and MBS9511022, respectively).
Techniques: Derivative Assay, Control